DDB is a chinese hrebal treatment used in treatment of hepatitis B, the aim of this work is to assess its efficacy and safety alone and in combination with amantadine and ribavin in patients with chronic HCV for 3 months. It was found effective in lowering AST and normalization of ALT in all patients with no effect on viremia and mild side effects. Addition of anti viral agents to DDB proved to decrease viremia and even clearance of viremia in 10-15% of patients with mild side effects.