Therapy-related myeloid neoplasms (t-MN) is the term proposed bythe 2008 W.H.O classification to cover the spectrum of malignant disorderspreviously described as therapy-related myelodysplastic syndrome(t-MDS)or therapy-related acute myeloid leukemia (t-AML) which occur as a latecomplication following cytotoxic therapy by alkylatingagents,topoisomerase-II inhibitors &immunosuppressants. Eight geneticpathways are involved in the pathogenesis leading to chromosomaldeletion,gain or translocation. It is generally a fatal disease with poorsurvival. Allogenic haemopoeitic cell transplantation is the most likelytreatment.