Psoriasis is a chronic inflammatory skin disease characterized by red scaly plaques, which may occur on any site of the body; prevalence is about 2–3% in Caucasians. Adiponectin is an adipocyte-specific secretory protein abundantly present in the circulation, decreased in obesity, insulin resistance and type 2 diabetes and hypoadiponectinaemia is assumed to be closely associated with the metabolic syndrome. Leptin is another adipocyte-specific secretory protein that decreases appetite and increases energy expenditure, and serum leptin levels reflect the body fat mass.This study was done on 36 patients and 30 apparently healthy controls. All patients and controls were subjected to clinical examination in which height, weight, body mass index, waist circumference and blood pressure were measured. Also serum levels of adiponectin and leptin was done by ELISA technique where as lipid profile and fasting blood sugar were measured using regular laboratory methods.In this study we detected that adiponectin and leptin has no role in pathogenesis of psoriasis or in determining severity of the disease as we detected no difference in serum adiponectin and leptin level between patients and control also no correlation between serum levels of adiponectin or leptin with disease characteristics (age of onset, duration, extent and PASI score) was detected. There is a positive correlation between adiponectin, leptin and some metabolic disorders. In conclusion from this work, Egyptian patients with psoriasis are not at increased risk of metabolic and cardiovascular complications, compared to the general population and that both groups are at increased risk of cardio-metabolic complications.