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Right ventricular diastolic abnormalities in patients with systemic sclerosis : Relation to left ventricular involvement and pulmonary hypertension

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Rheumatology & Rehabilitation

Advisors

Hasan, Samya Z. , Abdu, Manal M. , Abdel-Aziz, Magdi A.

Authors

El-Sawi, Wael Sadeq

Accessioned

2017-03-30 06:21:38

Available

2017-03-30 06:21:38

type

M.D. Thesis

Abstract

Introduction: systemic sclerosis is a generalized disorder of connective tissue characterized clinically by thickening and fibrosis of the skin and by distinctive forms of involvement of internal organs, among which is the heart. Manifestations of scleroderma heart disease are quite variable, and often not seen until late in the course of the disease. Purpose: this work aimed to assess the prevalence of right ventricular diastolic abnormalities in patients with systemic sclerosis and to investigate the relation to left ventricular affection, pulmonary hypertension and the clinical manifestations of the disease. Methods: our study group comprized thirty four patients with systemic sclerosis and thirty healthy subjects who served as controls. All the study groups were subjected to full history taking, clinical examination and cardiac ultrasound. Echocardiography was used to detemine left and right ventricular functions. Results: right ventricular diastolic abnormalities were found in 23 patients (67.65%) while left ventricular diastolic abnormalities were found in 11 patients ( 32.35%). A statistically highly significant correlation was found between patients and controls in ratio of time velocity integral of right atrium to right sided whole diastolic filling (P= 0.0001) and ratio of tricuspid early to late diastolic filling (P=0.0001). A significant correlation was found between right ventricular diastolic abnormalities and age of patients.Conclusion: Right and left ventricular diastolic abnormalities were found to be frequent more than expected and the presence of right ventricular diastolic abnormalities did not necissate their presence in the left side. As the age increases, the possibility of right ventricular diastolic dysfunction increases.

Issued

1 Jan 2004

Details

Type

Thesis

Created At

31 Jan 2023