Unfortunately, there is an increase in discontinua¬tion of use of the LNG-IUS because of hormonally related effects, particularly mood changes, acne and headaches. The incidence of these side effects, however, may be not higher than base¬line. Amenorrhea which is another significant cause of discontinuation may be per¬ceived by patients as a benefit rather than a compli¬cation of therapy especially if they are properly counseled. The LNG-IUS progestational activity furnishes the device with non-contraceptive indications as well. It is of proven therapeutic usefulness for menorrhagia and early investigations indicate it will also likely benefit patients with endometriosis. Both the LNG-IUS and the GnRH analogues were effective in the treatment of CPP associated endometriosis, although no differences were ob¬served between the two treatments. The LNG-IUS does not provoke hypoestrogenism and requires only one medical intervention for its introduction every 5 years.