Hepatitis C infection is one of the commonest chronic viral infections all over the world. It constitutes a major health problem in Egypt, since it is the most common cause of chronic liver disease among egyptians. Which in turn causes significant morbidity and mortality. The aim of the present work was to study HCV among those apparently healthy, asymptomatic subjects who carry positive antibodies against HCV. This study was conducted on 60 patients (38 males and 22 females), their ages ranged from 20 to 57 years, all apparantely healthy with no symptoms suggestive of chronic liver disease. The studied patients were subjetced to full history taking, with special emphasis on risk factors of hepatitis, full clinical examination, complete liver functions, PCR (qualitative and quantitative), abdominal ultrasound, ultrasonographic guided liver biopsy, and genotyping for HCV in some cases. From our results it could be concluded that :1)HCV is more prevalent among males.2)Surgical and dental procedures with or without blood transfusion is the most prevalent risk factor among egyptians now-a-days for disease transmission.3)Liver enzymes are not always elevated in infected cases, but when elevated they reflect the degree of hepatitis activity or hepatic fibrosis.4)Antibodies against HCV may be misleading in some cases, and the most accurate method is PCR which is more sensitive. 5)Asymptomatic Anti-HCV positive patients may be cirrhotic. 6)There is no relation between the sonographic findings and disease activity or histopathologic entity. 7)There is no relation between the PCR quantitation and the levels of liver enzymes or hepatitis activity in the histoapthology.8)The most prevalent genotype among egyptians was genotype 4a.