The liposomes are microscopic vesicles made by a double phospholipidic layers identical to the phospholipids that make up cell membranes which may encapsulate aqueous solutions, their size range from 500nm to 1000nm in diameter that serve as convenient delivery vehicles for biologically active compounds such as proteins nucleotides and even plasmids. Liposomes were proposed as drug carriers to modify the therapeutic index of a drug by reducing toxicity or increasing efficacy (or both) of the parent drug. Liposomes are used widely in diagnostic and therapeutic applications in medicine.In dermatology, liposomes used widely and are so promising in the future, they showed great success in treatment of the following diseases: Acne- Allergy- Alopecia- Angiosarcoma -Atopic Dermatitis- Cosmetics- Infection- Kaposi sarcoma – Melanoma- Oral ulcers- Psoriasis- Sunscreens- T. Cell lymphoma- Wound Healing- Xeroderma Pigmentosum.