Background : Hypeuricemia is a common problem among renal transplant recipients, and may adversely affect graft survival. Its prevalence is clearly attributable to cyclosporine (CsA) use, although individual patients may have other risk factors as well. Hyperuricemia may add on to several other factors in contributing to progressive deterioration of graft function and ultimately graft loss. Patients and methods : A cohort study was performed on 60 post-transplant renal recipients in the transplantation outpatient clinic , Kasr Al Aini Hospital. This study aimed to assess the prevalence of hyperuricemia and gout in renal transplant patients and to correlate between hyperuricemia and patient variables such as cyclosporine level, dyslipidemia, diabetes mellutes and renal impairment. 60 patients were analyzed including 40 (66.6%) males and 20 (33.3%) females with mean age of 32±12 years. We measure serum uric acid levels in each routine visit approximately every six months for two years in the transplantation outpatient clinic. Also we Measure cyclosporine level, blood sugar, lipid profile and kidney functions (urea, creatinine). We also record the general characteristics of the patients, history of gout and diabetes, underlying renal disorders, donor type, diuretic prescription, type of immunosuppressive regimen and urate lowering therapy. The patients were divided into two groups : group (A) : patients on cyclosporine, steroid & azathioprine. Group (B) : patients on cyclosporine, steroid & MMF (cellcept). Results : We found that mean uric acid level in all patients in the 1st year post-transplant is 6.2±1.7, while the mean uric acid level in the 2nd year post-transplant is 7±1.8 with percentage of change of 12% in uric acid level during the two years. There is a statistically significant difference between the 1st and 2nd year post-transplant with increase uric acid level from the 1st to the 2nd year.We found that patients with hyperuricemia represent 65% of the studied cases. Also we found that there was a significant positive correlation between mean uric acid post transplant versus cyclosporine, cholesterol and creatinine. On the other hand there was no significant correlation versus other variables such as age, sex and donor type. Conclusion : We concluded that there is a significant increase in the prevalence of hyperuricemia in post-transplant renal recipients.