The increased incidence of bacterial infections among patients with renal failure suggests that "professional" phagocytes such as neutrophils are functionally impaired. This dysfunction is multifactorial and not fully understood and has been ascribed to uremic toxins, hemodialysis and others. The aim of the current study was to evaluate apoptosis and phagocytosis in uremic neutrophils; neutrophils of hemodialysis patients and those who are not dialyzed yet, and apoptosis inducing activity of uremic plasma and to investigate the correlation between apoptosis and phagocytic function of neutrophils in uremic patients.The study was conducted on forty patients ranging (40-60) years old and divided into four groups; 10 chronic hemodialysis patients for 26.2 months, 10 chronic renal failure patients not hemodialyzed yet, 10 normal healthy volunteers as a control group, and 10 normal healthy volunteers as a control group for normal healthy volunteers.Neutrophils from hemodialysis patients, non hemodialysis patients and matched healthy volunteers were processed for quantification of apoptosis and phagocytosis. The neutrophils from different groups were incubated for 24 hours in culture media supplemented with either autologous or heterologous plasma from matched pairs from other groups. After the incubation period, neutrophils aliquots were processed for quantification of apoptosis and phagocytosis.We found that neutrophils of non-dialysis patients exhibited a significant higher apoptosis rates than neutrophils from hemodialysis patients and normal healthy volunteers. Also, neutrophils of hemodialysis patients exhibited a significant higher apoptosis rates than neutrophils of normal healthy volunteers. Moreover, plasma of non-dialysis patients is more apoptogenic than hemodialysis patients and normal healthy volunteers. Also, plasma of hemodialysis patients is more apoptogenic than normal healthy volunteers. Also, we observed that normal neutrophils of hemodialysis patients exhibited a significant lower phagocytosis rates than neutrophils of non-dialysis patients and normal volunteers. Also, neutrophils of non-dialysis patients exhibited a significant lower phagocytosis rates than normal neutrophils. Our study showed that plasma of non-dialysis patients has more suppressive effect on phagocytosis than plasma of hemodialysis patients and normal healthy volunteers. Also, plasma of hemodialysis patients has more suppressive effect on phagocytosis than plasma of normal healthy volunteers. But, neutrophils of hemodialysis patients are more prone to suppressive effect on phagocytosis than non-dialysis patients and normal healthy volunteers. While, neutrophils of non-dialysis patients are more prone to suppressive effect on phagocytosis than neutrophils of normal healthy volunteers. We concluded that there is significant inverse correlation between apoptosis and phagocytosis in all studied groups. This suggests that there is significant inverse correlation between neutrophil apoptosis and neutrophil functions. This suggests that apoptotic neutrophils are dysfunctional.