Background and aim: The contribution of renal biopsy is of major importance in many renal diseases in children. In our study we aimed to evaluate retrospectively the indications and the spectrum of histopathological findings of percutaneous ultrasound-guided renal (PRB) biopsy during a 10 year period as well as to analyze specific groups of renal patients.Patients and Methods: All cases of percutaneous renal biopsies (PRB) performed between 2002 and 2012 aged between 2 months and 18 years with available enough data in the filing system were studied. Demographic data, indications for renal biopsy, and histological diagnosis were obtained from their files.Results: A total of 875/1000 renal biopsies were studied. In 41.6% of the children renal biopsy was performed because of Nephrotic syndrome [50% SRNS, 14.1% Atypical age (<2 years or > 10 years), 11.4 % SDNS, 5% Nephrotic Syndrome with nephritic symptoms and with impaired KFT 4.5%], second most common indication was SLE 14.7%, third was Impaired kidney function 11.2% (98 cases, 70 with Acute kidney injury (71.4%), and 28 with Chronic kidney disease 28.6% of cases with impaired kidney function), Hematuria represent the indication for 74 cases (8.4%) with different pictures (persistent or recurrent, microscopic or gross hematuria).A renal pathology diagnosis was established in 76.7% of renal biopsies, while 13% were reported to have minimal change (MC) or no change under light microscopy. The most frequent types of biopsy-proven renal diseases were: Mesangio-proliferative glomerulonephritis (MPGN 21.6% of cases) Most of them were between 5 and 10 years. Minimal change or no change under light microscopy 13.3%, most of them were less than 5 years old, Lupus Nephritis with different classes as a cause of secondary GN represent 13.1% of cases, 80.9% of them were females, Focal Segmental Glumerulo-sclerosis in 11% of cases, most of them between 5 and 10 years, then with less percentages interstitial nephritis IN (6.6%), Acute diffuse proliferative Glumerulonephritis ADPGN (3%), Hemolytic Uremic Syndrome HUS (2.4%), Crescentic GN (1.8%), Membranous nephropathy (1.7%), Renal amyloidosis (1.6%), Congenital nephrotic syndrome FINNISH type (1.6%), Nephronophthisis (1%), and mesangiocapillary Glumerulonephritis (MCGN) , Focal proliferative Glumerulonephritis (FPGN),and others (12.4%) include cystic renal disease, infarcted kidney, infected hydronephrosis, lymphomotous infiltrate and tubular injury, 10% of cases needed another biopsy.Number of samples taken during doing the biopsy ranged from 1 sample to 4 samples, mean number of glomeruli found in the samples was 20 (minimum 1 and maximum 85).It was noticed that in MPGN male to female percentage was 66.3% to 33.7% respectively, while in SLE females represent 80.9% of the total cases of SLE, in HUS males represent 57.1%, while females represent 42.9%, in FSGS 51.5% were males and 48.5% were females.Conclusions: This study provides updated epidemiological information for childhood renal disease and revealed that Steroid Resistant Nephrotic Syndrome is the most common indication for Percutaneous Renal biopsy in our hospital, MPGN is the most common pathology, with rising number of FSGS.