The specificity of antigen recognition by lymphoid cells ismediated by surface expressed antigen receptor onImmunoglobulin (Ig) or T- cell receptor (TCR) whose diversityresults mainly from clone specific somatic rearrangement (Davisand Bjorkman, 1988). This rearrangement occur during the earlyphases of lymphoid differentiation and involves multiple anddispersed V, J and in some cases D segment that all togetherencode the variable portion of antigen receptor