Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. One of such genes is the lamin A and C gene located on chromosome 1q21, a susceptibility locus for type 2 DM and encodes nuclear lamins A and C. The LMNA 1908 C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome and obesity, suggesting that this polymorphism increase the risk of atherosclerosis and vascular disease. The present study aims to elucidate the association between the LMNA 1908 C/T SNP and the prevalence of vascular complications in type 2 diabetic patients. Genomic DNA from 47 type 2 diabetic patients with vascular complications and 20 control subjects was analyzed for LMNA 1908 C/T polymorphism using PCR-RFLP. Carriers of LMNA 1908 T-allele showed a significantly higher prevalence in patients with diabetic nephropathy than carriers of C-allele (P <0.05). Multiple regression analysis showed that the LMNA 1908 T-allele tended to be independent risk factor for diabetic nephropathy (P=0.012, O.R.=5.460). Conclusion: The findings of this study suggest that the LMNA 1908 C/T SNP is associated with the development of diabetic nephropathy in Egyptian type 2 diabetic patients.