Chondroprotection is a somewhat new field in the therapy of osteoarthritis, which is designed to improve cartilage repair as well as enhance joint remodeling. It clearly results from both laboratory models as well as from studies on human osteoarthritis, that cartilage contains biological resources to meet the repair of degenerative injuries and inflammation. Interestingly, sulfated glycosaminoglycans from matrix inhibit leukocyte protease and complement- mediated immunological reactions. The mechanism of chondroprotection may be prevention of subchondral bone resorption by osteoclast and also an altered destruction of bone marrow cells thus bisphosphonates currently appear to have potential as prophylaxis and treatment for osteopenia and joint damage in inflammatory arthritis. Several studies have reported that hyaluronan has beneficial effect on the cartilage during osteoarthritis development. Exogenous hyaluronan has been used as a lubricative agent but is also known to delay the degeneration of cartilage by inhibition of the release of glucose aminoglycans from articular cartilage tissue. And has anti-inflammatory effect.