Infertility is defined as failure of conception despite free unprotected sexual life, Among many cases, uterine factor and anatomic distortion of the uterine cavity which predisposes in some cases to implantation failure accounting for about 10% of cases whereas tubal factor accounts for up to 25% of cases of infertility. Pelvic adhesions, endometriosis and congenital malformations of the tube are another causes of tubal factor infertility. The uterus is a fibromuscular organ, lined with endometrium where its superficial layer undergoes cyclic monthly changes with the menstrual cycle, uterine causes of infertility include congenital uterine anomalies, uterine adhesions and uterine fibroids. This study aims to evaluate the role of hysterosalpingography, sonohysterography and diagnostic hysteroscopy in uterine cavity and fallopian tube assessment and to compare all of these parameters in the diagnostic work-upof secondary infertile patients. The methods used in this study to assess the uterine cavity and the fallopian tubes in secondary patients include hysterosalpingography which remained for a long time as the basic method of evaluation of infertile patients, Sonohysterography is another method of assessment in our study, greatly it assists in such diagnostic problems. Instillation of sterile saline in the uterine cavity via a fine catheter was greatly helpful in diagnosis of uterine pathologies and tubal patency, Sonohysterography only has the disadvantage of which pain, discomfort and vasovagal attack rarely occurs. Diagnostic hysteroscopy remains the gold standard in evaluation of the uterine cavity, Difficult visualization, orientation and misinterpretation are common problems with diagnostic hysteroscopy, contraindications to diagnostic hysteroscopy include pregnancy, pelvic infections, uterine perforation and heavy bleeding. Perforation, bleeding and endouterine contamination are the possible complications of diagnostic hysteroscopy. Our study included 50 patients in Kasr El Aini outpatient clinic, assessed with hysterosalpingography, sonohysterography and diagnostic hysteroscopy as gold standard in the fallopian tube. Patients were divided into two groups, - Group A assessment of uterine cavity- Group B assessment of fallopian tubeThus, sonohysterography offers a number of benefits over hysterosalpingography as a screening test in infertile patients. A number of hysteroscopic studies have demonstrated that the use of hysterosalpingography results in a high rate of false positive findings, additionally it is difficult to make a definitive diagnosis when interpreting hysterograms, we found that although hysterosalpingography was diagnostic for intrauterine synechiae, most other cavitary defects require further evaluation. In addition, to the diagnostic limitation of hysterosalpingography, this test require ionizing radiation and often accompanied by peritoneal irritation, it is also associated with more painful cramping than sonohysterography, from an imaging point of view, the major advantage of sonohysterography over hysterosalpingography is the visualization of the myometrium, the external contour of the uterus and the adnexal. The use of sonohysterography may reduce unnecessary hysteroscopies performed for false-positive or misleading findings as hysterosalpingography.