Recurrent Spontaneous abortion referred to 2 or more successive Spontaneous abortion.RSA may lead to in fertility and even shock.The update cause of RSA focused on antoimmune mechanism and chromosomal abnormalities.Diagnosis of RSA Nowadays include many new modern method for example, karyotyping by flow cytometry.Genetic engineering play great role in ttt. of Spontaneous abortion.Low dose Aspirin, heparin is new fassion of managament of anti phospholipid syndrome.