The uterine cervix is a uniqe organ composed predominantly of extracellular matrix proteins, collagen, elastin and glycosaminoglycans. During pregnancy the cervix, remains firm and closed to ensure that the product of conception is retained intrauterine until term. By the end of pregnancy the cervix undergoes considerable preparatory changes at the anatomic and molecular level which results in its softening and shortenig to be safely delivered. Pre-operative treatment with a primary agent, used to soften and dilate the cervix, has been shown to decrease morbidity associated with pregnancy termination including hemorrhage, incomplete uterine evocuation, perforation and cervical trauma.