Objective: The aim of the work is to study the microvascular and macrovascular changes in patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Research design and method: This study was conducted on 25 subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance, 10 males and 15 females with age ranging from 32 years and 52 years old, compared with 16 normal healthy individuals, 7 males and 9 females with age ranging from 30 years and 50 years old, both subjected to duplex study of the carotid intima media thickness (CIMT) on both sides and Laser Doppler flowmetry (LDF) study of the microvascular circulation. . Results: The study revealed that there is statistically significant difference between subjects and controls as regard the microvascular perfusion by LDF, microalbumenuria and CIMT Duplex study with P value less than 0.05. Conclusion: Prediabetics are having significant change in macrovascular circulation (increased CIMT) and microvascular circulation (decreased in LDF measurements, microalbumenuria) when compared to the control group.