Background: The growth of the Internet has impacted almost every facet of life in the world. This technology has changed the way people interact, shop, search for jobs, get directions, how they work, and how they spend leisure time. In most cases, utilization of the Internet has improved people’s lives with its ease of use and ever-growing amount of content. However, in some cases excessive use of the Internet has been linked to significant impairment in critical areas of functioning including mental, social, academic, career, and physical health. Aim of the work:The aim of this study is to determine the prevalence of pathological use of the internet and verify if there is a relation between this problem and the depressive disorders in the targeted population. Subjects and Methods: Participants were 300 Cairo university house officers. The internet addiction test (IAT) was used to measure pathological intent use.The Beck Depression Inventory (BDI-II) and Present State Examination-10 (PSE-10) were used to measure depression. The Internet Application Checklist was used to determine internet usage patterns of the subjects. Results: 54.0% of the sample was pathological internet users. Only 12.3% was moderate/severe pathological internet users. Severe forms of pathological internet use were more prevalent in males than females. Pathological internet users were more associated with depression and depressive disorders than non pathological internet users.Conclusion and recommendations: Based upon these findings, there were significant positive correlations between Internet addiction, depression, and depressive disorders in college student population. As universities are often an important line for the identification of potential harmful behaviors among students, college-based health professionals need to be cognizant of measures and procedures for the assessment of Internet addiction and depression