Vitiligo is a common hereditary pigmentary disorder. It occurs 1-2% among whites and higher in blacks. It is often familial but exact inheretance is unclear. There are three major theories concerning the etiology. The current study is concerned with the neural theory and how a neurotrophine (Nerve Growth Factor) affects the pathogenesis of vitiligo. Nerve growth factor is a peptide hormone formed of 18 amino acid. It is absolutely required for the survival of sympathetic neurons during development and throughout life, it also has a role in tissue repair and fibrosis. Regarding vitiligo, we measured the amount of NGF in vitiligenous lesions and non vitiligenous skin in vitiligo cases and compared the results with those of control healthy skin.Nerve growth factor was significantly highly expressed in vitiligenous lesions than that in non vitiligenous and control skin favouring that nerve growth factor may play a role in pathogenesis of vitiligo. This may open a potential field for further investigations for new treatments of vitiligo patients in the future.