Background : the aetiopathogenesis of psoriasis is still not fully understood. It has been reported that prolactin hormone (PRL) and growth hormone (GH) exert a proliferative effect on human kertinocytes ; therefore, they may play an important role in pathogenesis of psoriasis. The aim of our study was to assess the serum prolactin and growth hormones levels in patients with psoriasis. Methods : Serum levels of prolactin and growth hormones were estimated in 60 patients with psoriasis (age:11-77 years with a mean of 42.1 and a SD of15.53 years, sex : 40 males, 20 females) compared with 20 normal control subjects (age:15-50 years with a mean of 30.54 and a SD of 10.72 years,sex:10 males , 10 females). Results : the mean serum PRL in psoriatic patients was 210.15 µIU/ml while in the normal control subjects it was 17.85 µIU/ml . This difference was statistically highly significant (P= 0.0001). The mean serum GH in psoriatic patients was 2.43 ng /ml and in normal control subjects it was 2.45 ng / ml . This difference was statistically non significant. Conclusion: since PRL belongs to the growth hormone family, its raised serum level may have a role in the hyperproliferation of kertinocyte , the hallmark of psoriasis disease process . In our study GH has no role in pathogenesis of psoriasis ,however other studies are recommended to clarify the role of both hormones in the aetiopathogenesis of psoriasis .