The present work was designed to study the histological and ultrastructural changes in the kidney of the adult female albino rat, following intravenous administration of urografin and the possible protective role of nebivolol if used concomitantly with urografin.Fifty adult female albino rats were used in this study. They were divided into five groups, ten rats each; group І (normal control),group П(dehydrated sham) dehydrated for 3 days, group Ш(dehydrated nebivolol treated group) dehydrated for 3 days and received nebivolol by oral route at a daily dose of 2 mg/kg for 5 days, group ІѴ(dehydrated contrast medium administration group) dehydrated for 3 days and injected urografin intravenously at a dose of 6 ml/kg at day 4,group Ѵ(dehydrated contrast medium and nebivolol administration group)dehydrated for 3 days ,received nebivolol by oral route at a dose of 2 mg/kg for consecutive 5 days and injected urografin intravenously at a dose of 6 ml/kg at day 4.