Background & Aim: The degree of liver fibrosis is the strongest indicator of risk for hepatocellular carcinoma (HCC) development. Recently developed transient elastography (Fibroscan, Echosens, France) noninvasively measures liver stiffness, and the correlation between the stiffness and liver fibrosis stage has been validated. In this cross-sectional study, we aimed to investigate the relationship between liver stiffness and HCC presence.Patients & Methods: Routine laboratory investigations and Imaging were done in chronic hepatitis C patients (100 with HCC "GII" and 100 without "GI"). Liver stiffness was measured by transient elastography in both groups. Multivariate logistic regression was applied to assess the association with HCC presence. We computed the receiver operating characteristics (ROC) curves concerning the prediction of HCC presence. We also calculated stratum-specific likelihood ratios (SSLR).Results: Multivariate analysis showed that HCC presence was significantly associated with liver stiffness (P<0.001) along with alpha-fetoprotein concentration. SSLR for HCC presence by liver stiffness was 0.0128 in <10 kPa, 0.8189 in 10.1 to 15 kPa, 4.285 in 15.1 to 25 kPa, and 15 in >25 kPa.Conclusions: Liver stiffness measured by transient elastography is useful in demarcating chronic hepatitis C patients at a high risk for HCC, who require frequent check-up by imaging examinations.