Well differentiated thyroid carcinoma is the most common tumor of the thyroid gland, it’s potentially curable disease. Patients are classified according to the risk stratification. Age, sex, pathologic type, histopathologic characteristics (capsular, vascular invasion, lymph node involvement and staging) and extent of surgery are main risk factors which affect the response rate. Radioiodine-131 is the standard diagnostic method following surgery to evaluate extent of residual functioning thyroid tissue. 131I WBS is more sensitive than 99mTc-MIBI in detecting residual functioning thyroid tissue. The addition of serum Tg level to the 99mTc-MIBI WBS in the follow up of the patients following complete ablation increases the specificity of both diagnostic tests in assessment of recurrent or metastatic lesions. Lack of anatomical detailed in standard I-131 whole body scanning interfere with proper localization of metastatic differentiated thyroid carcinoma lesions . In addition, nearby or overlapping variable physiological bio-distribution of I-131 sometimes may interfere with certainty of extra-thyroidal foci of I-131 uptake giving indeterminate (equivocal) results. Precise localization of the foci of 131I uptake for management of patients with differentiated thyroid carcinoma can be difficult because of a lack of anatomic landmarks. The objective of the present study was to demonstrate the clinical usefulness if 131I images in patients with differentiated thyroid carcinoma. The diagnostic advantages of this technique seemed to be more apparent in dorsal as well as pelvi-abdominal region but of limited value in the neck & extremities.