Background: In the latest years jugular vein valve incompetence has been associated to many neurological disorders such as idiopathic intra cranial hypertension, transient global amnesia, and cough induced headache. It was hypothesized that impeded venous return from the brain may play a causal role in the etiology of IIH. The intact valve efficiently prevents retrograde flow into the internal jugular vein. Objectives: The aim of this study is to assess jugular vein valves as regard their presence and competence and their relationship with age, BMI, opening CSF pressure and MRV findings in IIH patients. Subjects and methods: Twenty five female patients suffer of IIH and twenty four normal females matched for age and BMI participated in the study. Included patients were submitted to clinical evaluation, laboratory work up, MRI and MRV .Duplex ultrasonography of the internal jugular veins done to all patients and controls. Results: JVI was detected in Seven IIH patients (28%) and five of the controls (20.8%). No significant difference was detected between patients and controls regarding the presence of jugular valve incompetence (P=0.7). Statistically highly significant positive correlation was detected between the presence of JVI to the opening CSF pressure and MRV abnormalities (P=0.03 , P=0.007 ) respectively. Conclusion: This preliminary study showed that JVI is a finding in IIH patients and normal subjects. Further studies are recommended to verify if JVI is a direct cause or just play a role in the pathophysiology of IIH.