Background: Coronary artery disease (CAD) is the leading cause of morbidity and mortality in both women and men. Numerous epidemiological and clinical studies have shown that there are significant differences between men and women in risk factors, therapies, disease manifestations and prognosis of acute myocardial infarction. During acute coronary syndromes, women had more back and jaw pain ,nausea and/or vomiting, dyspnea, indigestion, and palpitation ,also they reported dizziness, fatigue, loss of appetite and syncope. Whereas, men reported more chest pain and diaphoresis during myocardial infarction. Method: Open interviews with 80 patients STEMI were held during their hospital stay from July to October 2010. The interviews were aimed To examine gender-related differences in clinical features of patients admitted to the coronary care unit with acute ST-segment elevation myocardial infarction(STEMI) in Kasr Alainy hospital.Results : The studied groups of patients include 50 men(63%) and 30(27%) women. The age of patients ranged from 25 years to 72 years. The mean age was 58 years. Most of males presented with typical anginal chest pain and most of females presented with atypical chest pain. Ten percent of females and 8% of males presented with non chest pain symptoms .Most of males (66%) presented with Killip I and most of females (60%) presented with Killip ≥II (II, III or IV) . Most of males presented with chest pain radiating to the left shoulder AND most of females presented with chest pain radiating to the back. There was significant difference among two groups regarding receiving streptokinase. Males who receveied streptokinase more than females. On the other hand 10 % of males and 10% of females were transferred for PCI .The mean length of hospital stay in females was significantly longer than that of males.Conclusions: Females have less typical symptoms of AMI than males; it may be attribute by mistake to musculoskeletal, gastrointestinal, or neurologic diseases. Females with AMI present to hospital later than males and receive late and less aggressive treatment. Females were more prone to have morbidity and stay more time at hospital.