Background Hepatic cirrhosis is the end-stage of chronic liver diseases. Liver transplantation has been the most effective treatment for these patients but is critically limited by the shortage of available donor. The transplantation of autologous bone marrow-derived stem cells holds great potential for treating hepatic cirrhosis. •Methods Twenty patients with end stage liver disease that underwent autologous mesenchymal stem cells transplantation when infused into the peripheral vein. Subjects were patients with liver cirrhosis with abnormal liver functions. G-CSF was administered to patients to mobilize their haematopoietic stem cells (HSCs) from the bone marrow into the peripheral circulation for five days. BMSCs were aspirated and separated then injected into the peripheral vein and another twenty patients with end stage liver disease as control group was given standard medical treatment (diuretics, liver support… etc) in addition to 5 days S.C. injection of saline. After stem cell therapy, liver function was monitored for six months. Results There was significant improvement as regards serum albumin, bilirubin, PC, INR, ALT folds level, ascites, MELD score, Child score and performance score and non-significant improvement as regards serum AST folds between both groups. Safety of the procedure was evidenced by the low incidence of complications in form of fatigue, malaise, bony aches and fever. Serum creatinine of all patients was within the normal range. Conclusions Bone marrow stem cell therapy may be considered a novel treatment for patients with decompensated LC.