Background: The concept of KS as a genuine malignancy has been disputed. Several clinicopathological features indicate that KS, at least in the early stages, is a hyperplastic proliferation. Bcl2 is a protein that prevents apoptosis, while P53 is another protein that promotes it. Objective: Examine the levels of expression of Bcl2 and P53 in order to find a possible role of these two proteins in the progression of KS from hyperplastic proliferation to frank malignancy.Patients & Methods: Twenty kaposi’s sarcoma patients (6 with patch lesions, 5 with palques and 9 with nodules) and ten age and sex-matched controls were included in this study. One biopsy specimen was obtained from each of the 20 patients and the 10 controls. Three slides were made from each biopsy, one stained with Hx. & E. for microscopic examination, while the other two were prepared for immunohistochemical study of P53 and BCL2 proteins.Results: Expression of both P53 and BCL2 in kaposi sarcoma was higher than the controls. There was a detectable difference between expression of P53 and that of BCL2 in both kaposi sarcoma endothelial cells and spindle cells.Conclusions: P53 and Bcl2 may have a role in the pathogenesis of Kaposi’s sarcoma. They can be considered markers of disease activity.