Asthma is one of the most common chronic pediatric disease, asthma is influenced by genetic and environmental factors. Molecular genetics help to identify DNA sequence variants that constitute the genetic risk factor for the development of asthma and allergy. Familial concordance of disorder can be due to shared environmental as well as shared genes. Several quantitative traits associated with asthma phenotype have been linked to markers on the long arm of chromosome 11q13, within a region linked to atopy and increase airway responsiveness, the gene of Clara cell secretory protein (CC16) is an ideal candidate for involvement in an inherited predisposition to asthma owing to its chromosomal location, nature and function. The recent genetic study methods used for detection of allelic polymorphism using PCR and restriction digestion enzyme (Sau 961) has highlighted the association between CC16 polymorphism and increased risk of physician diagnosed asthma and its relation to asthma severity.