HCV is a leading cause of liver cancer and cirrhosis, and Egyptpossibly has the highest HCV prevalence worldwide. The effectivenumber of HCV infections in Egypt underwent rapid exponential growthbetween 1930 and 1955. The timing and speed of this spread providesquantitative genetic evidence that the Egyptian HCV epidemic wasinitiated and propagated by extensive antischistosomiasis injectioncampaigns. Although the results show that HCV transmission has since decreased, HCV is likely to remain prevalent in Egypt for several decades(Pybus et al.,2003). Mixed cryoglobulinemia, renal syndromes, lymphoproliferativedisorders, Sjogren syndrome, porphyria cutanea tarda, and neuropathiesare all strongly associated with HCV infection. Diabetes, thyroid disease,and the presence of autoantibodies in the serum are also linked to HCV,but less strongly. The pathophysiologic basis for most of these syndromesseems immunologic. Cirrhosis and chronic HCV infection seem to be risk factors (Ali and Zein, 2005). HCV can cause membranoproliferative glomerulonephritis(MPGN), membranous GN, cryoglobulinemic GN (MPGN) and there is also some reports of IgA nephropathy, fibrillary and immunotactoidglomerulopathy (Warren , 2003). RT recipients with anti-HCV antibody have an increased risk ofmortality and graft failure compared with HCV antibody negativepatients (Fabrizi et al., 2005).