The anesthesiologist can use either supraclavicular or infraclavicular blocks satisfactorily. This helps a lot when a local cause like swelling, infection, or obesity prevents the use of either of them, the other approach would work. In conclusion, both supraclavicular and infraclavicular approaches to the brachial plexus provided comparable satisfactory sensory and motor block in patients with chronic renal failure undergoing creation of arteriovenous fistula of the distal upper extremity. Both blocks provided very good analgesia that extended for a long time postoperatively. Patients were satisfied with both blocks and no complications were reported.