Essential Hypertension is a multifactorial disorder arising from the influence of several susceptibility genes and environmental stimuli. Genes may contribute up to 30% of variation of blood pressure. Apo E plays an essential role in clearance of chylomicron remnants and VLDL. Apo E gene has three alleles (E2, E3, and E4) that give rise to 6 different genotypes. A significant association of E4 allele has been observed with hypertension in addition to the other well known risk factors and positive family. These observations emphasize the need of Genotyping Apo E in patients with essential hypertension as an important molecular tool in personalized medicine. The study was conducted on 50 patients with essential hypertension. TheE3/E3genotype was found to be (85.42%), compared to (80%), E3/E4 (12.00%) and E2/E3 (8%) were higher in controls compared to in patients. E4/E4 and E2/E2 genotypes were only found in two patients (2%).TC and LDL were significantly higher in E3/E4 compared to in E3/E3 and E2/E3.However there was no significant difference in TG, HDL and VLDL.