Vitiligo is a disease of unknow etidogy. That affect 0.5-5% of the people world wide. In vitiligo, previous reports shown reduced catalase activity in the epidermis of the vitiligo patients, while there was imbalance of the both enzymatic and non enzymatic antioxidants and suggested that, this imbalance could be the source of the damage of the cells. Owr study we studied the relation between antioxidants and vitiligo. Our study included 15 patients with vitiligo and 10 normal control subjects. For each one of them we estimated the serum & tissue catalase and lipid proxide levels. We found, decreased tissue and serum catalase levels and elevated tissue and serum lipid peroxide in patients with vitiligo which suppose a positive role of both local and systemic antioxidants in treatment of vitiligo.