Vertigo is a complex symptom manifested in a host of disorders. Three senses are used to convey streams of sensation: visual, vestibular, and somatosensory. When there is a mismatch between information carried on two or more senses, vertigo is perceived. Drug treatment is aimed to manipulate neurotransmitters to lessen the symptoms of vertigo.Vestibulosuppressants consist of three major drug groups, the anticholinergics, the antihistamines and benzodiazepines.They are the mainstay of treatment of vertigo. In addition to acetyl-leucine and histamine agonists used to treat episodic vertigo.