Bronchial asthma is a chronic inflammatory disease of the airways, which reflects the importance of corticosteroids as being the first line choice for anti-inflammatory therapy for long-term prophylactic treatment in persistent asthma; however, their risks must be carefully considered, especially regarding bone metabolism and growth suppression in children. The aim of the present study was to compare the formation and degradation markers of bone turnover in children with asthma who are using inhaled fluticasone propionate (FP), as well as to study the effect of inhaled FP on short term statural growth, and the degree of improvement in pulmonary functions.The present study included 34 asthmatic children (group I), 18 males and 16 females, of the age group 6-12 years, who were further subdivided into two groups: a) Group Ia: receiving fluticasone propionate (FP), via metered dose inhalers (MDI), at doses equal to or below 200 mcg/day (19 patients), and b) Group Ib: receiving FP at doses above 200 mcg/day (15 patients). The study also included 14 healthy, non-atopic, non-asthmatic children (group II) as controls. They were 8 males and 6 females of the same age group.The results of the present work demonstrated a statistically significant decrease in asthma symptom score in both subgroups, as well as improvement of all asthma symptoms. A statistically significant increase in mean weight was observed in both subgroups, that was within the normal percentiles. Total patients achieved a mean increase in weight of 116.03+/-71.11% to that predicted. Similarly, a statistically significant increase in mean height was observed in both subgroups, that was within the normal percentiles. Total patients achieved a mean increase in height of 99.35+/-24.48% to that predicted. However, no statistically significant increase in mean BMI was demonstrated in either group. As regards pulmonary functions, a statistically significant increase in mean PEFR, FEV1, FEV1/FVC, and FEF25-75 was detected after treatment. No statistically significant difference between pre- and post-treatment mean values of serum calcium, phosphorous, and alkaline phosphatase was demonstrated. However, a statistically significant decrease in post-treatment mean values of both PICP and ICTP as compared to pretreatment values was observed implying a decrease in rate of bone turnover. Moreover, a statistically significant positive correlation was demonstrated between post-treatment levels of PICP and ICTP, and this “coupling” in decreased rate of formation as well as degradation implies no net bone loss.