One of the common aberrations seen in non-Hodgkin'slymphoma (NHL) is t(14;18)(q32;21.3). The aim of this work is tostudy the incidence and quantity of t(14;18) in B-NHL. 33 patientswith B-NHL and 10 controls with non-neoplastic lymphoid tissuedisorder were tested for quantitation of t(14;18) by real-timequantitative PCR (RQ-PCR). The incidence of t(14;18) was 6.1%among NHLs, 14.3% among follicular lymphomas (FLs), 5.6% amongdiffuse large cell lymphomas (DLCLs) and 10% among control group.The value of relative quantification for patients was (1.20 and 0.85),while for control case was (0.6). RQ-PCR is a sensitive and specificprocedure. It is an ideal tool for follow-up and quantification ofminimal residual disease (MRD).