The aimTo assess and compare the cost effectiveness of the different strategies for prenatal screening of fetal and pregnancy complication, and to determine the most useful protocol for. And to introduce antenatal rapid aneuplidies detection (ARAD) by QF-PCR test into routine practice to our community.Methods: 200 pregnant females were included; they were subjected to ultrasound scan for nuchal translucency (NT) nasal bone (NB) and b-hCG at 11-14weeks gestation AND for ultrasound scan for soft markers, major anomaly with maternal serum alpha feto protein (MSAFP) at18 -22weeks and at 26-28weeksResults: we divided cases into two groups, group A who is subjected to NT, NB and β-hCG at 11-14weeks gestation and was 99 cases. Group B who is subjected to ultrasound scans for soft markers, major anomaly with maternal serum alpha feto protein (MSAFP) at18 -22weeks and at 26-28weeks and was 193 cases. There are 5 cases with increased NT, two cases with decreased free β-hCG, three cases with increased free β-hCG, there are 9 cases with decreased MSAFP, amniocentesis was offered to all of them but three cases refused.Conclusion: The combination of ultrasound and biochemical screening works better than either one alone either in 1st or in 2nd trimester. 2nd trimester ultrasound screening can detect most of the structural abnormalities as NTD, Renal anomalies. QF-PCR is a rapid technique in the prenatal diagnosis of chromosomal aneuploidies. It allows the detection of the most common fetal numerical abnormalities with specificity 100% and sensitivity 100%.