Hepatic cirrhosis is the end-stage of chronic liverdiseases. Liver transplantation has been the most effective treatment forthese patients. Since liver transplantation is critically limited by theshortage of available donor livers searching for an effective alternativetherapy has attracted great interest in preclinical studies. Thetransplantation of autologous bone marrow-derived stem cells holds greatpotential for treating hepatic cirrhosis. We report thirty patients with end stage liver disease thatunderwent autologous bone marrow stem cells (BMSCs) transplantationin the portal vein. Subjects were patients with LC with abnormal liverfunctions. G-CSF was administered to suitable patients to mobilize theirhaematopoietic stem cells (HSCs) from the bone marrow into theperipheral circulation for three days (group 1) and five days (group 2).BMSCs were aspirated and separated then injected. After stem celltherapy, liver function was monitored for nine months. There was significant improvement as regards serumalbumin and non-significant improvement as regards bilirubin levels,INR, Prothrombin concentration, AST and ALT folds level. Safety of theprocedure was evidenced by the low incidence of complicationsencountered: serum creatinine of all patients was within the normal range. Bone marrow stem cell therapy may be considered anovel treatment for patients with decompensated LC.