Objective: To analyze the elevations of BNP and cTn-I in patients with sepsis, and septic shock and evaluate their relationships with echo data and outcome. Methods: 43 patients diagnosed to have sepsis (group I) or severe sepsis and shock (group II) admitted to Critical Care Department (Cairo University) from October 2007 to April 2009, in addition to ten healthy volunteers (group III). All patients were subjected to APACHE II, MODS,SOFA, O/A and day 2,echo O/A, as well as BNP and cTn-I O/A, and day 2. Results: BNP level O/A was significantly higher in groups I,II than group III; BNP level day 2 was higher in group II than group I. cTn-I in day 2 was higher in group II than group III.BNP level O/A and day 2 correlated inversely in both groups with Abe; as well as with pH.BNP levels O/A and day 2 had negative correlation in both groups with PC.BNP levels day 2 had a positive correlation in both groups with PT. BNP and cTn-I correlated positively with APACHE- II, MODS, SOFA (O/A and day2). cTnI O/A was inversely proportional to LVEF and LVFS, whereas Neither BNP O/A nor at day 2 correlated to LV diameters, volumes, LVEF, FS,CO or CI. BNP at day 2 was directly proportional to cTn-I at day 2.BNP and cTn-I was higher in non-survivors than survivors but this has not statistical significance. Conclusion: BNP cannot be used as a marker of heart failure in septic shock, although BNP and cTn-I were higher in non-survivors yet without statistical significance.