Laryngeal carcinoma is the most common cancer affecting the head and neck region. It is most predominant in men in the fifth and sixth decades of life. Squamous cell carcinoma constitutes the majority of laryngeal malignancies. This study aimed at production of an accurate registry of laryngeal carcinoma cases received by the pathology department in El Kasr El Aini Hospital during the period from January 2004 till December 2008, with re evaluation of all the slides histologically. 297 cases were collected. The patient's age ranged from 23 to 90 years with male predominance (95.6%). 126 cases (42.4%) were transglottic, 91 cases (30.6%) were supraglottic, 73 cases (24.6%) were glottic, and 7 cases (2.4%) were subglottic. The predominant histopathologic type was squamous cell carcinoma (99.7%). This work may be put as a nucleus and linked with other registries of laryngeal carcinoma in different governorates in Egypt.