Aim of Work: Analysis of thyroid carcinoma cases in 5 years duration, to detect rate of occurrence of different types, to reclassify cases according to the latest grading and staging systems and to compare the clinicopathological features among Egyptian patients included in the study with registries of other countries. Methods: Slides and data were obtained from archives of pathology department, Faculty of Medicine, Cairo University, Kasr El Aini Hospitals (2004-2008).Results: Ninety-nine cases were studied and classified into 79 papillary carcinoma (PC), 8 follicular carcinoma (FC), 2 poorly differentiated carcinoma (PDC), 3 anaplastic carcinoma (AC), 6 medullary carcinoma (MC) and one biphasic carcinoma (BC). The most common clinical presentation was thyroid nodule/s and many cases were incidentally discovered within multinodular goiter or thyroiditis. The mean age of patients was 43.5 years and the age of patients ranged from 17 to 75 years. The highest mean age was present in anaplastic carcinoma cases. The female to male ratio was 2.8:1 (73 females and 26 males). The mean age of female patients (41.8 years) was significantly less than that of male patients (48.3 years). The mean tumor size was 2.8 cm and ranged from 0.3 to 7 cm. The least mean size was in PC cases. The histologic grade was defined as a summary of three histologic features (VAN); vascular invasion (V), marked nuclear atypia (A) and tumor necrosis (N). Seventy-one cases were categorized as VAN 1 (low grade) and 28 cases were categorized as VAN 2 (high grade). Fifty-one cases were categorized as stage I, 6 cases as stage II, 17 cases as stage III and 10 cases as stage IV. AMES scoring system was used for risk group stratification and showed that 51 cases (51.5%) were low risk and 48 cases (48.5%) were high risk. Subtypes of PC included: Conventional type (60.8%), papillary with follicular areas (11.4%), follicular variant (12.7%), microcarcinoma (11.4%), tall cell variant (2.5%) and diffuse sclerosing variant (1.3%). FC cases were classified as minimally invasive (2 cases) and widely invasive (6 cases) types.Recommendations: The statistically significant relationship between tumor stage and grade suggests the importance of documentation of tumor grade based on combined examination of nuclear atypia, tumor necrosis and vascular invasion, especially in well differentiated thyroid carcinomas.