Vitamin A and its metabolites have been shown to be teratogenic in animals and humans. In this work, 50 pregnant rats of the rattus norvigicus strain of both sexes were divided into three groups, each one consisted of 20 pregnant rats except the first group which consisted of 10 pregnant rats and used as a control. The first group was treated by corn oil, while the second and third groups were treated by 50 mg/kg/day, 100 mg/kg/day retinol palmitate respectively during the period of organogenesis from the 8th to13th day of gestation. In conclusion, Vitamin A has a potent teratogenic effect in the cranio-facial region in a dose exceeding 10.000 IU/day. So, it should be given with great caution during pregnancy to avoid its hazardous effect.