The present study was performed to study the antibiotic regimen patternused in management of neonatal sepsis in NICU, Aboul-Rish UniversityHospital, Cairo University, and to correlate them to clinical data,laboratory data and outcome of cases of neonatal sepsis. The studyincluded 70 neonates who were diagnosed as neonatal sepsis whetherfrom the beginning of admission course or during their stay. The studywas conducted in the period from January 2007 to June 2007.The total number of cases admitted in this period was 494 neonatesof which 70 neonates had neonatal sepsis representing 14% of the totalcases. The number of males was 44 representing 62.9% of total casescompared to 26 females representing 37.1% of total cases. Thegestational age of the cases ranged between 29 and 40 weeks with meanof 35.4 ± 3.1 weeks. The number of full term was 29 representing 41.4%of total cases compared to 41 preterm representing 58.6% of total cases.