Colonic carcinoma including rectal carcinoma (Colo-Rectal Carcinoma) is one of the best studied conditions of multistage human carcinogenesis. K-Ras gene mutations are among the most common genetic alterations present in colorectal tumors. Ras genes codify for membrane-attached, small guanine triphosphate–bound proteins that play a key role in transduction of extracellular mitogenic signals. Ras mutations (mainly at codons 12, 13, and 61 of the K-Ras gene) that constitutively activate their function are present in a significant proportion of colorectal adenomas and carcinomasThe accumulation of such mutated protein can be detected by immunohistochemical staining in a significant proportion of cases. Apoptosis is a highly regulated cell suicide mechanism that is important for many biological processes, including embryonic development, response of tumors to cancer chemotherapy, and the pathogenesis of neurodegenerative diseases. The K-Ras has been recognized as a major oncogene involved in colo-rectal carcinogenesis arising from precancerous adenomatous changes and in randome cases. Fas mediated apoptosis is involved in programmed cell death among cases of IBD, Bilharziasis, and CRC, with high expression in IBD which play an important role in the disease progression, and with low expression in CRC through which the tumor cells can escape the host immune reaction.