Several studies described an association between acute ischemic stroke and elevated inflammatory markers. This study aimed at evaluating the relationship between inflammatory markers and pathogenesis of acute ischemic stroke, and whether they are correlated to the size of the infarction and severity of the stroke. Twenty patients as well as fifteen control subjects were submitted to history taking, general and neurological examinations, routine battery of investigations, measurements of C-reactive protein, fibrinogen, and IL-6. The results were correlated to both size of the infarction and severity of the stroke after three months. The inflammatory markers were higher in the stroke patients compared to the control group with a positive correlation to both size of the infarct and clinical outcome.