Since the detection and cloning hepatitis C virus (HCV) RNA by Choo 1989, this particular pathogen has been considered the main etiological factor for chronic liver disease. Global surveys have recorded an estimation of HCV infection about 2-3 % (~170 million individual). HCV infection has many devastating sequences on the general health and poses a significant risk of developing liver cirrhosis and hepatocellular carcinoma, these two are serious life threatening conditions.Oral health and dental treatment for patients with HCV infection is a matter of concern in endemic countries, also the risk of exposure to blood borne pathogens such HCV in dental sitting is considerably high. Anassociation was found between certain oral diseases and HCV infection such as Sjogren’s syndrome, oral lichen planus and oral squamous cell carcinoma. Generally speaking the oral hygiene and oral health seems to be below average among infected individuals compared to normal healthy persons.Egypt since the parenteral anti-schistosomal therapy (PAT) campaign in the 1960s have the highest prevalence of HCV infection, this correlation was suggested on the base of the findings of higher rates of HCV infection among adult Egyptian farmers males who lives in rural areas, as these group were the main target for the PAT campaign. This makes the high baseline for HCV prevalence among elderly people in Egypt, but despite the fact that the Egyptian population has been doubles in the past decades, Egypt still has the highest prevalence of HCV infection in the world, which suggests ongoing transmission among the population. The aim of the current study was to measure frequency and risk factors of Hepatitis C infection among a sample of undiagnosed Egyptian subjects seeking dental care, as we anticipate to encounter high rates of exposure to these risks in the age groups that seeks dental care.The participants were subjected to risk factor questionnaire to assess the frequency of the exposure to these risks, and blood samples were collected from every participant who reported previous exposure to any of the risk factors. Enzyme-linked immunosorbent assay (ELISA) was carried out to detect anti-HCV antibodies in the serum of exposed individuals. Socio-demographic variables and previous dental therapy for each participant were recorded, which revealed high rates of single visit therapeutic experience in different age and gender variables. Our results indicates association between increasing age, illiterate individuals and exposure to risk factors especially extra-oral surgery which has to be the only risk factor among the participants in this study who have the potential of HCV infection transmission.Different risk factors have been reported with significant association with positive anti-HCV antibodies, extra-oral surgery is the most encountered risk factor among the participants, followed by blood products transfusion in Egypt. This finding is consistent with previous community studies and seroprevalence studies carried out in Egypt in different sittings, this points out that the main exposure that correlates to HCV infection transmission among Egyptian population is invasive medical intervention.