Background: It has been shown that IL 4 and 5 and leucocyte adhesion molecules play an important role in the development of inflammation of bronchial asthma. The purpose of this study was to study the role of soluble ICAM-1 in bronchial asthma by measuring its level in serum and bronchoalveolar lavage, the effect of inhaled steroids on asthmatics using some of inflammatory markers (ICAM-1, interleukin 4 and 5 levels), finally the relationship between bronchial hyperresponsiveness and one of the inflammatory mediators (ICAM-1).Methods: This study was carried in Kasr El Aini Hospital, Cairo University where 30 individuals (20 asthmatics and 10 control) participates. They were divided into the following groups. Group I (10 control), Group II (10 asthmatics before and after 3 weeks of inhaled steroids) and Group III ( 10 asthmatics subjected to bronchoprovocation tests). All participants were subjected to full history taking, clinical examinations, full blood count, pulmonary function tests, bronchial provocational challenge (Group III), bronchoscopy and bronchoalveolar lavage. sICAM-1 was detected in serum and Bal in all groups. IL 4 and 5 levels were detected in BAL in Group II only. Results: sICAM-1 was raised in serum of asthmatics, there was no correlation between FEV1, PD20 and sICAM-1 but was correlated with eosinophilic count and IL 5. There was a reciprocal relationship between sICAM-1 in serum and BAL. There was reduction in the inflammatory markers (sICAM-1, IL 4, 5 and serum eosinophilic count) after 3 weeks of inhaled corticosteroids. Conclusion: sICAM-1 is one of inflammatory mediator but may be it is unsuitable to be used as an asthma severity marker. Inhaled corticosteroids are effective in controlling asthma symptoms, improving pulmonary function tests and reducing inflammatory mediators.