Objectives: Vacuum-assisted closure (VAC) was primarily designed for the treatment of pressure ulcers or chronic, debilitating wounds. Recently, VAC has become an encouraging treatment modality for sternal wound infection after cardiac surgery, providing excellent results. Methods: This was a prospective, randomized, descriptive study that enrolled a total of 20 patients with superficial and deep sternal wound infections under usage of VAC system as modality of treatment of sternal wound infection or preparing for conventional methods (omental flap or Myocutaneous flap) in the period between March 2013 till March 2014. Results: Ninteen patients (95 %) were treated successfully. One patient (5 %) died. The overall length of hospitalization was 30.4 days (range 16 to 49). The median number of dressing changes was 6.1 (range 3 to 10). The median VAC treatment time until surgical closure 25.9 days (range 14 to 45 days) .VAC therapy was used as definitive therapy also as a bridge to conventional methods. Conclusion: VAC therapy is a safe and reliable option in the treatment of sternal wound infection in cardiac surgery. VAC therapy should be considered as an effective primary modality of treatment of sternal wound infections and also effective adjunct to conventional treatment modalities for the treatment of extensive and life-threatening wound infections following cardiac surgery, particularly in the presence of risk factors.