Introduction: Epilepsy affects close to 1% of adolescents. Adolescentswith epilepsy (AWE) experience comorbid psychiatric disorders, themost common of which is depression. Epilepsy in adolescents isassociated with a perceived stigma of epilepsy and with low self-esteem.Objective: This study aims to evaluate depression, perceived illnessstigma of epilepsy, and self-esteem in a sample of AWE; and to evaluatethe association between depression and the latter two variables in AWE.Methods: This is a cross- sectional case- control study. Adolescents (14-22 years of age) with idiopathic epilepsy (AWE) in Kasr Al Ainyoutpatient epilepsy clinic were interviewed using The Structured ClinicalInterview for DSM-IV Axis-I Disorders to assess presence or absence ofdepression (depressive disorders). 30 AWE with depression and 30 AWEwithout depression (as controls) were recruited, using convenientpurposive sampling. The Internalized Stigma of Mental Illness scale wasused to assess perceived illness stigma of epilepsy and the RosenbergSelf-esteem Scale was used to assess self-esteem in both cases andcontrols. The AWE with depression were also interviewed by BeckDepression inventory and Hamilton Rating Scale for Depression.Results: Perceived (internalized) stigma of epilepsy is significantlyhigher (by the ISMI) and self-esteem is lower (by the RSES) in the AWEwith depression compared to the AWE without depression.Conclusion: Perceived illness stigma of epilepsy and self-esteem areassociated with depression in AWE