Background and Aim: Cirrhotic patients admitted to the intensive care unit (ICU) usually have multi-organ failure. Multiple organ failure entails a very poor outcome in all intensive care patients. Cirrhotic patients show high morbidity and mortality rates compared with other critically ill patients. The main aim of this study was to determine the efficacy of the SOFA score in comparison with liver specific scoring system (CTP and MELD scoring systems) and blood lactate level in giving any predictive value for mortality in cirrhotic elderly patients admitted to the ICU. Methods: In all the patients enrolled, a diagnosis of cirrhosis was confirmed either histologically or by resorting to clinical, laboratory, and ultrasonography findings. During this period, patients with cirrhosis were admitted to the ICU with varying indications. Child-Turcotte-Pugh (CTP), Model for End-stage Liver Disease (MELD), Sequential Organ Failure Assessment (SOFA) scores and lactate were compared between died and discharged patients. Results: A total of 40 patients were enrolled in this study. The mean age of all the patients was 55.7±10.8 years. We detected that HCV is the main etiological factor for cirrhosis. Hepatorenal syndrome and hepatic encephalopathy were significantly higher in patients who died than in those who were discharged from the ICU (p values were 0.001 and 0.007, respectively). Lactate level, CTP, MELD and SOFA scores were significantly higher in patients who died than in those who were discharged from the ICU (p values were 0.001 for all).Results of our study have shown SOFA calculated 48 hours after ICU admission to be the best prognostic model, among the scoring systems studied, at predicting prognosis in cirrhotic patients admitted to the ICU with AUROC values of 0.908 (p 0.001, 95% CI 0.769 – 1.00). Conclusions: Many factors may be useful as a predictor of mortality in ICU in patients with cirrhosis. In terms of prognostic value, the SOFA score is superior in comparison with MELD, CTP score and lactate.