Corticosteroid is a risk factor inducing femoral head osteonecrosis. The antioxidant Vitamin E could reduce such osteonecrosis. Sixty adult male albino rats were grouped into: GІ (normal control), GII (Sham control), GIII-MPSL subdivided into: (III-A -3 days) and (III-B-3 weeks), GIV (MPSL and vitamin E) subdivided into; (IV-A- 3 days) and (IV-B-3 weeks). GIII showed femoral head cortical and medullary pleopathological changes, which were reduced in GIV after vitamin E adminstration, being more in subgroup IV-B than IV-A demonstrating a duration dependency.